![]() The outcome is related to multiple factors such as metastasis, size, lymph node involvement, and the like ( 9, 10). In this regard, there are different grading systems such as Mandard, Dowrak, Dowrak/Rodel, and tumor regression grading (TRG) ( 8). The pathological studies among patients with preoperative chemoradiotherapy have shown a significant reduction in the number and size of involved lymph nodes and frequency of lymph node metastasis ( 7). Pathological complete response (pCR), ranging from 10 to 30 percent, would increase the survival and decrease the recurrence rate ( 6). The main benefit of preoperative chemoradiation is complete clinical regression and pathological response ( 5). The risk of postoperative recurrence rate is high) ranging from 4 to 27 percent (and preoperative chemotherapy is a useful method to improve the survival and reduce the recurrence ( 3). ![]() Dietary is one of the important environmental factors and studies have shown that a healthy dietary pattern can reduce the risk of colorectal cancer and colorectal adenoma, on the other hand, the “western” dietary pattern can increase the risks ( 4). Multiple risk factors including environmental and genetic issues have been involved in the pathogenesis of the disease ( 3). However, there are multiple screening methods to reduce the morbidity and mortality of these cancers ( 2). BackgroundĬolorectal cancers are the third common malignancies after lung and breast neoplasms ( 1). Rectal Cancer, Tumor Location Neoadjuvant Chemoradiotherapy 1. According to the obtained results in this study, there may be some association between rectal tumor location and pathologic complete response.
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